Equipments

U1. Protein Production Platform (PPP)

U1.E05. Tangential filtration Unit for purification

U1.E04. FPLC ÄKTA Chromatography systems for purification

U1.E03. Incubator shaker with cooling unit for insect cells suspension cultures

U1.E02. 10 liter WAVE bioreactor for insect cells

U1.E01. 2 and 7 liter bioreactors for bio production

U2. Custom Antibody Service (CAbS)

• U2-E01. Cell culture laboratory for hybridoma production.
• U2-E02. HiClass II Type A2 Biological Safety Cabinet (2 units)
• U2-E03. Inverted Microscope Leica DM IL LED with CCD camera
• U2-E04. CO2 cell culture incubator with UV contamination control (2 units)
• U2-E05. AKTA Prime FPLC system for purification of proteins
• U2-E06 Tangential Flow Filtration System (KrosFlo® Research Iii)
• U2-E07. Laboratory fully equipped for immunochemical methods.
• U2-E08. Laboratory perfectly equipped for chemical synthesis (to hapten synthesis)
• U2-E09. Animal facility.

U3. Synthesis of Peptides Unit

• U3-E01. Automatic synthesizer
• U3-E02. High-performance liquid chromatography (HPLC) systems with a diode array detector.
• U3-E03. High-performance liquid chromatography (HPLC) system with dual-wavelength UV detector
• U3-E04. High-performance liquid chromatography (HPLC -MS) system with a diode array detector and coupled to a mass spectrometer
• U3-E05. Bohdan miniblocks
• U3-E06. Lyophilizers and SpeedVac evaporators
• U3-E07. System for acidolactic cleavage (Boc/Bzl strategy), UNIQUE IN SPAIN
• U3-E08. Amino acid analyzer and MALDI -TOF for characterization
• U3-E09. Microwave peptide synthesizer

U6. Biomaterial Processing and Nanostructuring Unit

• U6-E01. High-pressure laboratory-scale plant with 50, 100 and 300 ml reactors for the processing of biomaterials
• U6-E02. High-pressure phase analyzer for studying the thermodynamic behaviour of materials
• U6-E03. Malvern Zetasizer Nano ZS particle size analyzer
• U6-E04. Nanosight LM -20 for Nanoparticle Tracking Analysis
• U6-E05. Nanosight NS-300 for Nanoparticle Tracking Analysis by fluorescence mode
• U6-E06. Perkin-Elmer DSC 8500 differential scanning calorimeter
• U6-E07. Olympus BX51 optical microscope with heating plate and fluorescence accessories
• U6-E08. Perkin-Elmer LS 45 fluorescence spectrometer
• U6-E09. Varian Cary 5 UV -Vis spectrometer
• U6-E10. Quantachrome Ultrapyc 1200e helium pycnometer
• U6-E11. Ultrasound probe and Autotap instrument for packed density measurements of powders
• U6-E12. Malvern Morphologi G3 for advanced particle morphologi characterization
• U6-E13. Microcalorimeter for measurements under Isothermal Titration Calorimetry (ITC)
• U6-E14. Four Glove Dispensing isolator for expermiments with highly active and cytotoxic compounds

U7. Nanotechnology Unit

• U7-E01. Ebeam/SEM (Nova NanoSEM 230/Raith)
• U7-E02. ToF-SIMS (Time of the Flight Secondary Ion Mass Spectroscopy)
• U7-E03. UV optical Lithography (Mask Aligner)
• U7-E04. Laser Lithography (Mask Plotter)
• U7-E05. Wet Bench
• U7-E06. Thermal and e-beam metal evaporator
• U7-E07. Spin-coater
• U7-E08. Plasma Cleaner
• U7-E09. Interferometer
• U7-E10. Profilometer
• U7-E11. Optical Microscopy
• U7-E12. Oven
• U7-E13. UV Curing Lapm System
• U7-E14. Microarrayer SPOTBOT2
• U7-E15. Contact Angel (OCA15 plus)

U8. Micro/Nanotechnology Unit

• U8-E01. Chemical vapor deposition (CVD) equipment for growth of CNTs and Graphene, Black Magic Pro 4-inch System ( AIXTRON Ltd)
• U8-E02. Thermal oxidation process equipment.
• U8-E03. Platinum and gold deposition equipment
• U8-E04. Optical photolithography equipment
• U8-E05. CVD nitride and oxide passivation equipment
• U8-E06. Chemical banks for micro/nanotechnologies
• U8-E07. RIE and DRIE equipment
• U8-E08. Nanolithography equipment
• U8-E09. Optical (SEM) and electrical (Impedance) characterization equipment
• U8-E10. Encapsulation equipment
• U8-E13 Spin coater for Polyimide depositon (W6-650-23B, Laurell Technologies Corp.)
• U8-E14. Oven for Polyimide curing in inert conditions (Ovenvan N67, Ovan).
• U8-E15. Dual extrusion 3D printer (Ultimaker S3, Ultimaker BV)

U9. Synthesis of Nanoparticles Unit

• U9-E01. Reactor for laser-induced pyrolysis for controlled synthesis of nanoparticles
• U9-E02. System for measuring of adsorption and drugs delivery
• U9-E03. Two instruments for liquid-phase synthesis of nanoparticles
• U9-E04. Two spectrometers ZER 3000 HS and a Brookhaven 90PLUS PCS
• U9-E05. Micromeritics ASA P 2020 analyzer
• U9-E06. System for the thermal and optical characterization of core-shell metallic nanoparticles by surface plasmon resonance
• U9-E07. Software for data acquisition and processing from PCS , BET

U10. Drug Formulation

• U10-E01. Cell culture laboratory
• U10-E02. Flow cytometer
• U10-E03. Dripper electrostatic
• U10-E04. Autoclave
• U10-E05. Fluorescence inverted microscope imaging system
• U10-E06. Inverted microscope with imaging system
• U10-E07. System for processing micro and nanoparticles by atomization
• U10-E08. Spray-dryer
• U10-E09. High pressure homogenizer
• U10-E10. Freezedryer
• U10-E11. Particle size analyzer in solid
• U10-E12. Coulter Particle size analyzer
• U10-E13. Particle size analyzer and Zetasizer
• U10-E14. Compression Tablet machines (eccentric and rotary)
• U10-E15. Fluid Bed
• U10-E16. Coating machines
• U10-E17. Capsules machine
• U10-E18. Blister packing machine
• U10-E19. One step mixer Granulator
• U10-E20. Liquid chromatograph with fluorescence detection
• U10-E21. Liquid chromatographs with UV detection
• U10-E22. Liquid chromatograph with electrochemical detection
• U10-E23. HPLC-MS
• U10-E24. HPLC-MS/MS
• U10-E25. UPLC
• U10-E26. GC-MS, GC-NPD
• U10-E27. Dissolution test Equipment
• U10-E28. Desintegration tester
• U10-E29. Friabilometer
• U10-E30. Durometer
• U10-E31. Determination of moisture equipment
• U10-E32. Viscometer
• U10-E33. -80 º C Freezers
• U10-E34. Climate chambers with temperature and humidity control
• U10-E35 Confocal Microscopy Unit
• U10-E36. Regemat 3D V1 Bioprinter
• U10-E37. 3D Bioprinter
• U10-E38 Equipment of biopharmaceutical characterization of pulmonary formulations with Breath Simulator and Alberta Idealised Throat (AIT)

U11. Pharmaceutical Lab

• U11-E01. Precision balance
• U11-E02. pH-meter
• U11-E03. Magnetic stirrer
• U11-E04. TI LAZO Temperature IKA TC 3 (YELLOW LINE)
• U11-E05. Rotary shaker
• U11-E06. PGW Balance (ADAM)
• U11-E07. Logger Temperature
• U11-E08. Thermohygrometer
• U11-E09. Freezer 2-8 ºC

U12. Nanostructured liquid characterization unit

• Design of parenteral MNP-loaded PLGA nanoparticles by a low-energy emulsification approach as theragnostic platforms for intravenous or intratumoral administration
• U12-E01. 3D cross-correlation dynamic light scattering (DLS) spectrometer
• U12-E02. CytoViva Hyperspectral Imaging System (HSI)
• U12-E03. AR-G2 Rheometer
• U12-E04. Malvern 4700 Spectrometer
• U12-E05. Mastersizer 2000 Light Diffractometer
• U12-E06. S3 Micro SAXS/WAXS Small and Wide Angle X-Ray Spectrometer
• U12-E07. SITE Spinning Drop Interfacial Tensiometer
• U12-E08. Contact angle goniometer and drop shape analyzer
• U12-E09 Sigma 701 force tensiometer (Biolin Scientific) for the measurement of surface and interfacial tensions, wettability and critical micelar concentration
• U12-E10. Optilab rEX Differential Refractometer
• U12-E11. Densitometer DMA 4500M (Anton Paar)
• U12-E12. BX51TRF6 Olympus Optical Microscope
• U12-E13. Turbiscan Lab backscattering stability analyzer (Formulaction)
• U12-E14. Avanti J30I ultracentrifuge (Beckman Coulter)
• U12-E15. SEM Hitachi TM-1000 (Hitachi)
• U12-E16. Autosorb IQ (Quantachrome Instruments)
• U12-E17. Zetasizer NanoZ (Malvern Instruments)
• U12-E18. Viscosimeter RVDV-II+P (Brookfield)
• U12-E19. HPLC 1525 Series (Waters)
• U12-E20. Osmometer Type 15 (Löser Messtechnik)
• U12-E21. Fluorimeter Cary Eclipse (Varian)
• U12-E22. SEM Hitachi TM4000Plus II for morphological and dimensional characterization of solid samples

U13. Tissue & Scaffold Characterization Unit

• U13-E01. MicroCT GE eXplore Locus SP (GE)
• U13-E02. Machines for mechanical tests
• U13-E3. Atomic Force Microscopy

U14. Cell Therapy

• U14-E01. Cell culture rooms
• U14-E02. Molecular biology

U16. Surface Characterization and Calorimetry Unit

• U16-E01. TAM III isothermal nanocalorimeter system. (TA Instruments)
• U16-E02. UVISEL ellipsometer (Horiba JovinYvon)
• U16-E03. K-Alpha X-ray photoelectron spectroscopy (XPS) system (Thermo)
• U16-E04. ToF-SIMS 5 Time-of-flight secondary-ion mass spectrometry system (ION TOF )
• U16-E05. DROP SHAPE ANALYZER – DSA100E (Remote) OUTSTANDING
• U16-E06. 3D Optical Surface Metrology System Leica DCM8 -Optical Profilometer- OUTSTANDING
• U16-E07. Equipment for microbiology tests on materials. OUTSTANDING

U17. Confocal Microscopy Service

• U17-E01. Leica TCS-SP5 confocal microscope

U18. Nanotoxicology Unit

• U18-E01. Cell culture rooms
• U18-E02. Autoclaves, refrigerators, freezers and liquid nitrogen tanks
• U18-E03. Dissection hoods
• U18-E04. Equipment for paraffin processing
• U18-E05. Equipment for cutting and staining histological sections
• U18-E06. Tip and bath sonicators
• U18-E07. Plate readers
• U18-E08. Electrophoresis systems
• U18-E09. Tissue Arrayer
• U18-E10. Olympus Microsocpe
• U18-E11. Abacus hematocytometer
• U18-E12. Decloaking Chamber NxGen (Anacron diagnostics)
• U18-E13. Immunofluorescenece supplement for Olympus Microscope

U19. Clinical tests lab

• U19-E01. General Laboratory equipment
• U19-E02. Solid state thermostatic equipment 37 º C + – 0,1 º C with magnetic stirrer system, 15 reaction cubiletes and a reacive bottle
• U19-E02. Specific laboratory diagnostic equipment: Hematology, biochemistry, hormones, biomarkers analyzer
• U19-E03. Automatic coagulometer (AUTOCLOT SP de RAL)
• U19-E04. Clinic auto-analyser (Metrolab 2300 de RAL)
• U19-E05. Blood cells counter (MEK-6318. NIHON KOHDEN)
• U19-E06. AQT90 FLEX analyzer (RADIOMETER)
• U19-E07. Water purification system (Elix 3 de MILLIPORE)
• U19-E08. Water purification system (Milli-Q Advantage A10 de MILLIPORE)
• U19-E09. Laboratory freezer (MEDILOW-M SELECTA)
• U19-E10. Vertical Freezer (SF-126) from -30 ºC to 150 L capacity
• U19-E11. Digital automatic micropipettes
• U19-E12. Centrifuge SELECTA (MIXTASEL 7000575)
• U19-E13. Rotary shaker (NAHITA)
• U19-E14. Recorder Device leukocyte (Leucoform 83 de CRISON)
• U19-E15. Binocular microscope (LEICA CM E BA 220/20 W)
• U19-E16. pH Meter (GLP 21 de CRISON)
• U19-E17. NPT7 Gasometer analyzer (RADIOMETER)
• U19-E18. i-STAT® 1 Analyzer (ABBOTT)
• U19-E19. Veterinary Hematology Analyzer (MINDRAY BC-5300VET)
• U19-E20. ABL80 FLEX Gasometer Analyzer (RADIOMETER)
• U19-E21. Urine Analyzer (DIRUI H-100)
• U19-E22. MAGLUMI, Chemiluminescence Analyzer (Snibe)
• U19-E23. Ultrafreezer -80ºC (Froilabo)

U20. In Vivo Experimental Unit

• U20-E01. Optical imaging equipment
• U20-E02. Equipment for histological processing
• U20-E03. Animal Facility
• U20-E04. General laboratory equipment

U21. Experimental operating rooms

• U21-E01. Experimental operating rooms for small and large animal
• U21-E02. Rooms for preparation and preanesthesia
• U21-E03. Sterelization rooms for medical instruments and tools
• U21-E04. Integrated operating room

U22. Animal housing

• U22-E01. Rooms for the maintenance of large animals
• U22-E02. Rooms for maintaining small ruminants
• U22-E03. Barrier zone for maintenance of rodentsunder SPF conditions
• U22-E04. Integrated operating room with in the barrier area
• U22-E05. Multi-use rooms for rodents and lagomorphs maintenance
• U22-E06. Room for receipt and handling of animals
• U22-E07. Quarantine rooms pre-experimental process
• U22-E08. Room to perform small procedures and cures and preparation rooms for large animals prior to the surgical area
• U22-E09. Metabolic cages to perform toxicity studies in rodents

U23. Assisted Reproduction

• U23-E01. Micromanipulator and microinyection of last generation in conjunction with the most advanced optical microscope IMSI system
• U23-E02. SATURN LASER systems to break zona pellicuda and biopsied embryos
• U23-E03. Vision systems of the mitotic spindle (Oosight system)
• U23-E04. Flow cabinets with stereo-microscopes and heated plates
• U23-E05. Incubators with different gasses systems
• U23-E06. Equipment and cryopreservation freeze gamete and embryo

U24. Medical imaging

• U24-E01. Fluoroscopy
• U24-E02. Digital subtraction angiography system
• U24-E03. Ultrasound scanner
• U24-E04. Computed Tomography (CT) scanner
• U24-E05. 1.5T Magnetic Resonance Imaging (MRI) system
• U24-E06. Cardiac electrophysiology lab with navigation (CARTO 3) and biotherapeutics delivery (NOGA XP) systems

U25. NMR: Biomedical Applications I

• U25-E01. Two AVANCE 250 MH z
• U25-E02. An AVANCE 360 MH z
• U25-E03. AVII 400 MH z
• U25-E04. AVIII 400 MH z
• U25-E05. AVANCE 500 MH z
• U25-E06. AVIII 600 MH z
• U25-E07. BioSpec 70/30 300 MH z
• U25-E08. Focused Microwave Fixation System
• U25-E09. Hypersense sample polarizer
• U25-E10. Animal housing
• U25-E11. Software packages

U26. NMR: Biomedical Applications II

• U26-E01. DRX-600 Bruker NM R equipment (14 Teslas)
• U26-E02. -NMR microscopy system for imaging Bruker 14T
• U26-E03. Bruker DRX500 spectrometer (11.7 T), and with three RF channels
• U26-E04. Bruker DPX300 spectrometer(7 T) with standard entrance, and two RF channels.
• U26-E05 Bruker Avance III 400 WB spectrometer, with ultrashielded widemouth magnet (89 mm), 400 MHz (9.4 T), with two RF channels and high power amplifiers for solid-state experiments.
• U26-E06. Gilson 215 liquid handler for automated sample preparation of liquid samples
• U26-E07. MRS*DRYMAG3017-Flexiscan

U27.  High Performance Computing

• U27-E01. Hermes cluster
• U27-E02. Open source software
• U27-E03. Licensed software

U28.  NanoImaging Unit

• U28-E01. Bruker BioSpec 9.4T animal MRI system
• U28-E02. Bruker In vivo Xtreme
• U28-E03. Bruker Albira small animal CT system
• U28-E04. Bruker Ascend 400 MHz NMR spectrometer
• U28-E05. Bruker Avance 600 MHz NMR spectrometer + HR-MAS Probe
• U28-E06. Bruker Minispec MQ-60
• U28-E07. FEI Tecnai G2 20 TWIN Transmission Electron Microscope + Cryo-TEM
• U28-E08. FEI Quanta 250 FEG Scanning Electron Microscope + ESEM Mode
• U28-E09. Leica FC7 cryo-chamber on Leica EM UC7 ultramicrotome
• U28-E10. Leica EM HPM100
• U28-E11. Leica EM AFS2
• U28-E12. FEI Vitrobot Mark IV
• U28-E13. Leica SP5 HyD Confocal Microscope
• U28-E14. Leica SP5 HyD MP Multiphoton Confocal Microscope
• U28-E15. Nikon Eclipse Ti TIRF Fluorescence Microscope + N-Storm
• U28-E16. Nikon Eclipse Ti basic Fluorescence Microscope
• U28-E17. Perkin Elmer Operetta HCS confocal
• U28-E18. Beckman Coulter Galios flow cytometer
• U28-E19. Beckman Coulter MoFlo cell sorter

U30.  Proteomics

• U30-E01. TIMS TOF Pro LC-MS/MS System
• U30-E02. QTRAP LC-MS/MS System
• U30-E03. MALDI-TOF/TOF System
• U30-E04. Small equipment for protein separation
• U30-E05. Small equipment for protein detection/quantification